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Restaurants · Louisiana, New Orleans

Domilise's Po-Boys and Bar

  • CuisinePo'boys
  • CategoryPo'boys
  • VibeGruff, unpretentious neighborhood corner joint
  • Rating★ 4.5
  • Price$ (about $12-20 per person; US$12-20)

Domilise's Po-Boys and Bar at 5240 Annunciation Street in the Uptown neighborhood of New Orleans, Louisiana, is a corner po'boy shop that has been in operation since 1918 and has been handed down within the Domilise family. It is one of the most loved neighborhood sandwich counters in the city and a reference point for what a po'boy should taste like.

Old-school Uptown corner po'boy shop in operation since 1918.

Domilise's Po-Boys and Bar at 5240 Annunciation Street in the Uptown neighborhood of New Orleans, Louisiana, is a corner po'boy shop that has been in operation since 1918 and has been handed down within the Domilise family. It is one of the most loved neighborhood sandwich counters in the city and a reference point for what a po'boy should taste like. The sandwiches are made to order on soft, crusty New Orleans French bread, dressed with lettuce, tomato, pickles and mayonnaise unless ordered otherwise. The fried shrimp po'boy is the signature, with crisp, juicy Gulf shrimp, and the fried oyster, hot sausage, roast beef with gravy and fried catfish versions are also popular. Roast beef is served drenched in gravy and is notoriously messy. A beer is the traditional pairing, and the small bar serves local brands. The building itself is a modest, weathered corner house in a residential block, with a short counter, a few tables and a back room, and the atmosphere is unpretentious and gruff in the best way, with framed photos and memorabilia on the walls. It has the feel of a local hangout, and the pace is unhurried, so lines build and orders can take a while at lunch. There is no dress code and no reservations. Service is counter style, and visitors should be prepared to wait and to bring cash, though payment options should be confirmed before going. The shop typically opens Monday through Saturday for lunch and early evening, and hours can vary, so checking before traveling is wise, especially because the location is a ride from the French Quarter. Expect to spend about US$12-20 per person. A visit is easily paired with a walk through the Uptown and Audubon Park areas or a streetcar ride along St. Charles Avenue. Regulars treat the shop as a community fixture, and visitors are expected to be patient, friendly and ready to order quickly once they reach the counter.

Practical information for Domilise's Po-Boys and Bar · Last updated September 2026
Price $ (about $12-20 per person; US$12-20)
Hours Typically Mon-Sat lunch and early evening; confirm before going
Reservations No reservations; walk-in, cash-friendly neighborhood counter
Address 5240 Annunciation St, New Orleans, LA 70115

Signature dishes

  • fried shrimp po'boy
  • hot sausage po'boy
  • fried oyster po'boy
  • roast beef

Good to know

Known for
Old-school Uptown corner po'boy shop in operation since 1918

Location

5240 Annunciation St, New Orleans, LA 70115

29.9242, -90.1112 View on map

Highlights

  • Po'boys served on the same corner since 1918
  • Fried shrimp and hot sausage po'boys made to order
  • Unpretentious Uptown neighborhood bar and counter
  • Messy, gravy-laden roast beef sandwich
  • Cheap, filling meal for about US$12-20

Tips for visiting

  • Arrive just before or after the noon rush to shorten the wait.
  • Order the po'boy dressed to get lettuce, tomato, pickles and mayonnaise.
  • Bring cash and confirm accepted payments before visiting.
  • Check opening days and hours before making the trip Uptown.
  • A half sandwich is plenty for many appetites.

When to visit

Mid-afternoon on weekdays is typically calmer than the lunch rush, which builds around noon.

Accessibility

The shop is a small, older corner building with limited space; visitors with mobility needs should call ahead to confirm access and seating.

Frequently asked questions

What should I order at Domilise's?

The fried shrimp po'boy is the signature. Hot sausage, fried oyster and roast beef are also popular.

Does Domilise's take reservations?

No. It is walk-in counter service.

What does dressed mean?

A dressed po'boy comes with lettuce, tomato, pickles and mayonnaise.

How do I get there from the French Quarter?

It is in Uptown, and visitors usually take a ride-share, taxi or the streetcar plus a short walk.