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Restaurants · North Carolina, North Carolina

Nana's Restaurant

  • CuisineNew American / Mediterranean
  • CategoryFine Dining
  • VibeGracious and refined, warm and enduring, classically European-inspired
  • Rating★ 4.5
  • Price$$$

Nana's is a Durham, North Carolina fine dining institution that has occupied its place on University Drive since chef Scott Howell opened it in 1992. One of the Triangle's longest-running upscale restaurants, Nana's has earned its longevity through consistent execution of Mediterranean-influenced New American cuisine and a wine program that remains among the most seriously assembled in the region.

Nana's Restaurant

Nana's is a Durham, North Carolina fine dining institution that has occupied its place on University Drive since chef Scott Howell opened it in 1992. One of the Triangle's longest-running upscale restaurants, Nana's has earned its longevity through consistent execution of Mediterranean-influenced New American cuisine and a wine program that remains among the most seriously assembled in the region. The name is a tribute to Howell's grandmother, and the restaurant carries that sense of warmth and familiarity even at its most formal. The menu draws freely on Mediterranean traditions while staying grounded in seasonal American ingredients: lamb rack is prepared with the precision of a classical French kitchen and the flavor palette of southern Europe. House-made pasta reflects Italian technique applied to local North Carolina grains and seasonal accompaniments. Pan-roasted halibut is executed simply and impeccably, allowing the quality of the fish to speak. The chocolate ganache tart is the dessert that ends most meals at Nana's and has become a signature of the kitchen's ability to be both indulgent and composed. The dining room on University Drive is gracious without being intimidating — well-appointed tables, proper linens, and attentive service that reflects three decades of refinement. The wine list is particularly notable, with depth across European regions and a selection of older vintages that make it a destination for serious wine drinkers in the Triangle. Reservations are recommended and can be made through the restaurant's website or by phone.

Signature dishes

  • Lamb rack
  • House-made pasta
  • Pan-roasted halibut
  • Chocolate ganache tart

Good to know

Known for
Mediterranean-influenced New American with excellent wine list
Hours
Tue-Sat 5pm-10pm; closed Sun-Mon
Reservations
Recommended; nanasrestaurant.com or (919) 493-8545

Location

2514 University Dr, Durham, NC 27707

35.9811, -78.9484 View on map

Highlights

  • Durham fine dining institution open since 1992 — one of the Triangle's most enduring upscale restaurants
  • Mediterranean-influenced menu with lamb rack, house-made pasta, and expertly roasted fish
  • One of the Triangle's most seriously assembled wine lists with depth in European regions and older vintages
  • Named for chef Scott Howell's grandmother — warmth and familiarity inform the service style
  • Chocolate ganache tart is the kitchen's signature dessert and a fitting close to a refined meal

Tips for visiting

  • Reserve through nanasrestaurant.com or by phone — weekends book up, particularly during Duke University events
  • Ask the staff to guide wine selections — the list has genuine depth and they are enthusiastic navigators
  • The lamb rack is a reliable signature that demonstrates the kitchen at its most classical
  • House-made pasta changes with the season — ask the server what is available before defaulting to the printed menu
  • For a special occasion, inquire about the tasting menu or extended chef's course options

Accessibility

The restaurant is located in a commercial building at street level. Guests with mobility concerns should contact Nana's ahead of their visit to confirm accessible entrance and seating arrangements.

Frequently asked questions

How long has Nana's been open?

Nana's opened in 1992 and has operated continuously for over three decades, making it one of the oldest upscale restaurants in the Triangle and a genuine Durham institution.

What is the wine list like at Nana's?

The wine list is one of the Triangle's most serious — organized by region with depth in France, Italy, and Spain, along with domestic selections and some older vintages for collectors.

Is Nana's appropriate for a business dinner?

Yes — the gracious dining room, attentive service, and serious wine list make Nana's a strong choice for business entertaining in Durham.

What does Mediterranean-influenced mean at Nana's?

Chef Scott Howell draws on the flavor profiles, techniques, and ingredient traditions of southern Europe — particularly France, Italy, and Greece — while using North Carolina and American seasonal ingredients.

Is parking available at Nana's on University Drive?

Yes — the University Drive location has parking available in the surrounding commercial area. Street parking and a lot adjacent to the restaurant are typically accessible.

Ready to book

Nana's Restaurant

Reserve on nanasrestaurant.com