Open Travel Guide
History of Missouri

Missouri History & Heritage Guide 2026

The history of Missouri told through its places: sites worth the detour and the context they need.

Missouri has 8+ historical sites covered in this guide, led by Gateway Arch National Park, Harry S. Truman Presidential Library & Museum and Mark Twain Boyhood Home & Museum. Each entry below includes the practical details — what it costs, when to go, and how to plan around it.

Missouri is the crossroads of the American heartland, where the Mississippi and Missouri Rivers converge and eastern woodlands give way to western plains. From the gleaming Gateway Arch in St. Louis to the Ozark Mountains' ancient caves and the world-class barbecue pits of Kansas City, Missouri packs an extraordinary range of landscapes, history, and culture into a single state.

Historical timeline

Key moments that shaped Missouri.

  1. 1

    French explorers Marquette and Jolliet become the first Europeans documented to enter present-day Missouri.

    1673
  2. 2

    St. Louis founded by French fur traders Pierre Laclède and René Auguste Chouteau as a trading post on the western bank of the Mississippi.

    1764
  3. 3

    Louisiana Purchase — the United States acquires Missouri and the vast Louisiana Territory from France for $15 million.

    1803
  4. 4

    Lewis and Clark Expedition departs from Camp Dubois (near the Missouri River mouth at St. Charles) and returns to St. Louis, opening the American West.

    1804–1806
  5. 5

    Missouri admitted to the Union as the 24th state under the Missouri Compromise (admitted as a slave state; Maine admitted as a free state simultaneously).

    1821
  6. 6

    St. Louis and Independence become the staging grounds for the Santa Fe, Oregon, and California Trails, funneling hundreds of thousands of westward migrants.

    1836–1860
  7. 7

    Civil War. Missouri formally remained in the Union but was bitterly divided. Guerrilla warfare (Quantrill's Raiders, Jayhawkers) devastated western Missouri. Battle of Wilson's Creek (1861) and Battle of Westport (1864) were major engagements.

    1861–1865
  8. 8

    Mark Twain publishes The Adventures of Tom Sawyer, drawing from his Hannibal boyhood and cementing the Mississippi River in American literary culture.

    1876
  9. 9

    Louisiana Purchase Exposition (World's Fair) in St. Louis attracts 20 million visitors. The ice cream cone, hot dog bun, and Dr. Pepper gain national exposure.

    1904
  10. 10

    Kansas City jazz scene emerges. Tom Pendergast's political machine drives economic growth and tolerates an open jazz and blues nightclub culture on 18th & Vine.

    1917–1920
  11. 11

    Harry S. Truman of Independence, Missouri serves as the 33rd President. Authorizes use of atomic bombs on Japan; oversees creation of NATO and start of Korean War.

    1945–1953
  12. 12

    Gateway Arch completed in St. Louis, designed by Finnish-American architect Eero Saarinen. At 630 feet, it remains the tallest man-made monument in the Western Hemisphere.

    1965

Historical sites

Places where Missouri's past comes alive.